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Brain health issue? Risky idiot 16/10/14(Fri)02:52 No. 13242
13242

File 147640632022.jpg - (99.04KB , 1920x1080 , wallhaven-143944.jpg )

Took a Modafinil today at 11:30 am. Tomorrow I was wondering if I would ok to take ecstasy at like 12:00 am or 1 am? Just wondering if my brain won't fry up. Thank you. Pic unrelated


>>
Anonymous 16/11/12(Sat)23:17 No. 13254

It's been a couple of days so I'm late to the party, assuming you've already done it (and you survived, it's just not too hot on your brainbox)

Modafinil induces many CYP450 enzymes, which MDMA is metabolized by. CYP3A4 is the main one that will cause problems, as this will lead to more N-demethylation to MDA, and consequently more toxic metabolites. So taking it will most likely change the effects of the roll to be more MDA-like, and will lead to more neurotoxicity.

Now let's just talk about the other effects. Modafinil has affinities for the NE and DA transporters, as well as the H3 receptors. MDMA's relative affinities for the NE and DA systems are going to be much higher, so it will cancel out the direct effects.

If you're going to do this, drink some grapefruit juice to inhibit CYP3A4, but ideally you should space them apart.





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