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The Locust are genetically engineered bio-weapons, making their anatomy a blend of human and subterranean Reptilian creature DNA, Not Human, The Cordyceps Constraint In The Last of Us, the Cordyceps Brain Infection (CBI) is a mutated fungus that specifically targets humans (and in some real-world variations, specific insects)."The Locustian bio-engineered quasi-entities (whose not-entirely-human hybridized somatic architectures arise from the deliberate intermingling of anthropoid genetic substrates with those of certain subterranean saurian-adjacent lifeforms, thereby rendering them categorically non-anthropic) must be understood only through the simultaneous lens of the Cordycepsian Constraint as dramatized within the narrative construct known as The Last of Us, wherein the so-called Cordyceps Brain Infection—itself a heavily mutated fungal agent preferentially oriented toward human hosts (and, under certain non-fictional entomological variants, toward particular arthropods)—imposes an analogous though non-identical ontological restriction upon the very possibility of pure humanity remaining uncompromised by either engineered reptilian admixture or mycological neural colonization.